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分子匹配的向治疗:对于耐火性转移性黑色素瘤来说,这是一个有前途的方法
Emily Connell1,2, Émilie Gerard3, Bénédicte Oules4
1Dermatology and Skin Cancer Department, Aix Marseille University, APHM, CRCM Inserm U1068, CNRS U7258, Marseille, France.
The oncologist
|May 18, 2024
概括
与分子变化相匹配的向疗法对抗标准治疗的晚期黑色素瘤患者有希望. 这种方法在38%的严重预先治疗的个体中实现了疾病控制.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 皮肤病学 皮肤病学
背景情况:
- 转移性黑色素瘤患者通常会从当前的治疗中获得有限的持久益处.
- 在黑色素瘤中,除了BRAF,NRAS或CKIT突变之外,个性化药物的临床实用性被低估.
研究的目的:
- 评估分子匹配向疗法的有效性,用于具有可操作分子变化的晚期黑色素瘤患者.
- 评估对标准疗法的耐药性患者的结果.
主要方法:
- 对接受分子匹配治疗的晚期黑色素瘤患者 (≥18岁) 的回顾性分析.
- 排除只有BRAF,NRAS或CKIT变化或治疗时间小于15天的患者.
- 分子测试确定了可操作的变化,指导了向治疗选择.
主要成果:
- 包括26名严重预治疗的患者;中位数随访时间为8个月.
- 38%的疾病控制率 (15%的整体应答率,6个月稳定的疾病).
- 控制的疾病与GNA11,MAP2K1,RAF1,HRAS,ATM,CCND1,MDM2/CDK4,CDKN2A/NRAS.的变化相关.
结论:
- 高通量测序和匹配的向治疗为晚期黑色素瘤提供了一个有希望的策略.
- 这种方法显示出治疗耐药性疾病患者的潜力.
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