精液等离子体金属/金属质和精液质量之间的关联:一个横截面研究
Juan Wen1, Xiaodie Yao1, Renjie Lu2
1Nanjing Women and Children's Healthcare Institute, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, Jiangsu 210000, China.
Ecotoxicology and environmental safety
|May 18, 2024
概括
接触,和等金属混合物可能会对精液质量产生负面影响,影响精子的运动性和度. 这项研究探讨了金属对男性生殖健康的个人和联合影响.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 职业医学 职业医学是专业的.
背景情况:
- 金属和金属合金是环境污染物,可能对人类健康产生不利影响.
- 之前的研究主要集中在单金属暴露对精液质量的影响上.
- 多重金属暴露对男性生殖参数的综合影响仍未得到充分研究.
研究的目的:
- 调查个人和混合金属/金属化物暴露与精液质量参数之间的关联.
- 为了确定有助于对精子产生不利影响的特定金属.
- 评估各种金属对男性生育指标的综合影响.
主要方法:
- 从中国东部的生殖中心招募330名男性.
- 测量25种金属/金属质的精液度,并评估精子参数.
- 应用通用线性模型 (GLM),受限立方支线 (RCS) 和加权量子总和 (WQS) 回归用于统计分析.
主要成果:
- 在 (Li), (Zn) 和 (Mg) 暴露和精子运动率降低之间发现了积极的关联.
- (Al) 与精子度和数量呈反向关系,而 (Co) 与精子度呈正相关.
- WQS模型显示,金属/金属化物混合物显著增加了异常渐进和总精子运动的风险,主要是由Li,Mg和Zn驱动的.
结论:
- 接触金属/合金混合物,特别是,和,与精液质量受损有关.
- 这些发现强调了在评估男性生殖健康风险时考虑联合金属暴露的重要性.
- 需要进一步的研究来阐明金属混合物对精子参数的不利影响背后的机制.
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