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FOXM1和CHD4的表达与肝细胞瘤中的化学抵抗有关

Yuko Hino¹, Kenichi Kohashi², Akihiko Tamaki³

¹Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Pathology, research and practice

|May 18, 2024

概括

叉头盒蛋白M1 (FOXM1) 可能预测肝细胞母细胞瘤 (HB) 的治疗反应. 高FOXM1表达与基斯基化疗的较差结果相关,这表明其在评估儿童肝癌治疗有效性的有用性.

科学领域:

在瘤学瘤学.
儿科病理学儿科病理学
分子生物学分子生物学

背景情况:

肝细胞瘤 (HB) 是最常见的儿科肝脏恶性瘤.
基于西斯普拉丁 (CDDP) 的化疗是标准的,但CDDP耐药性发生在约20%的HB病例中.
叉头盒蛋白M1 (FOXM1) 和染色域-酶-DNA结合蛋白4 (CHD4) 都与CDDP耐药性有关.

研究的目的:

在化学治疗后的儿科肝细胞母细胞瘤样本中研究FOXM1和CHD4的免疫组织化学表达.
为了将FOXM1和CHD4表达与瘤分化和化疗反应相关联.
评估FOXM1作为一种生物标志物在HB中CDDP治疗疗效的实用性.

主要方法:

在33名HB患者样本中对FOXM1和CHD4进行免疫组织化学分析.化疗后.
数字病理学软件 (QuPath®) 用于样本差异化评估.
蛋白质表达,临床病理学参数和化疗反应标记 (AFP,成像收缩,组织学残留率) 之间的相关性分析.

主要成果:

无论FOXM1和CHD4的免疫表达在胚胎的比胎儿的HB组件显著更高.
高的FOXM1分数与术后较高的α-fetoprotein (AFP) 水平和较低的AFP衰减率相关.
FOXM1表达与成像收缩或组织学残留率无关;CHD4显示非显著的趋势.

结论:

在肝细胞瘤中,FOXM1表达可以作为评估对基于CDDP的化疗反应的有价值指标.
准确的FOXM1量化,可能使用数字病理学,对于混合HB组件病例很重要.
对FOXM1的作用的进一步研究可以完善儿科肝癌的治疗策略.

关键词:

化学抗药性化学抗药性是一种抗药性.染色域-酶-DNA结合蛋白4 (CHD4) 是一种西斯普拉丁 (Cisplatin) 是一种叉头盒蛋白M1 (FOXM1) 是一种肝炎母细胞瘤是什么?

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