自我报告的认知功能调解了多发性硬化症患者的就业状况和认知功能之间的关系
Adrian I Espiritu1, Yasmin Soliman2, Mervin Blair3
1Ontario Shores Centre for Mental Health Sciences, Whitby, Ontario, Canada; Department of Psychiatry and Department of Medicine (Division of Neurology), University of Toronto, Toronto, Ontario, Canada; Department of Clinical Epidemiology, College of Medicine, University of the Philippines Manila, Manila, Philippines; Concussion Canadian Center, University Health Network, University of Toronto, Toronto, ON, Canada.
Multiple sclerosis and related disorders
|May 18, 2024
概括
多发性硬化患者自我报告的认知障碍部分解释了就业状态对认知表现的影响. 抑郁症也会影响这种关系,强调在解释自我报告的认知问题时考虑就业和情绪的重要性.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 康复医学 康复医学 康复医学
背景情况:
- 认知障碍 (CI) 在多发性硬化症 (PwMS) 患者中很普遍,影响他们的日常生活和就业.
- 自我报告的CI,客观认知表现和PwMS的就业状况之间的关系尚未完全理解.
- 自我报告的CI可能受到抑郁症等因素的影响,这可能会影响其作为认知功能的唯一指标的可靠性.
研究的目的:
- 调查雇佣状况是否会影响PwMS中的认知功能.
- 确定自我报告的CI是否调解了就业状态和客观认知表现之间的关系.
- 检查抑郁症在自我报告的CI和认知表现之间的关联中所起的缓和作用.
主要方法:
- 使用多发性硬化症神经心理学问卷 (MSNQ),医院焦虑和抑郁量表-抑郁量表 (HADS-D) 和MS认知功能的最小评估 (MACFIMS) 的590个PwMS的回顾性分析.
- 结构方程建模 (SEM) 用于分析就业状况,自我报告的CI,抑郁症和认知结果 (记忆,执行功能,处理速度) 之间的复杂关系.
- PwMS被分为就业或失业,统计模型对调解和调节效应进行了测试.
主要成果:
- 与失业者相比,雇佣的PwMS在记忆,执行功能和处理速度方面表现明显更好.
- 自我报告的CI (MSNQ) 部分介绍了就业状态对记忆力,执行功能和处理速度的影响.
- 抑郁症 (HADS-D) 缓和了自我报告的CI和认知表现之间的关联,表明抑郁症得分较高的人在主观和客观措施之间存在更强的联系.
结论:
- 自我报告的认知障碍部分解释了为什么就业状况会影响PwMS中的客观认知表现.
- 抑郁症在调节主观和客观认知评估之间的关系方面发挥着重要作用.
- 在解释MS患者自我报告的认知困难时,就业状况和情绪是必须考虑的关键因素.
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