产前母亲 炎症,儿童认知和青少年抑郁症状
Madeline R Pike1, Emily Lipner1, Kathleen J O'Brien1
1Temple University, Department of Psychology and Neuroscience, 1701 N 13th St, Philadelphia, PA 19122, USA.
产前孕产妇炎症可能会增加青少年抑郁症的风险,因为它会损害儿童的认知能力. 皮博迪图片词汇测试 (PPVT) 显示的儿童时期较低的认知分数部分调解了这一关联,突出了潜在的抑郁途径.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 产前母亲炎症与后代抑郁症风险增加有关.
- 这种炎症可能会对后代的认知发展产生负面影响,进一步提高抑郁症的风险.
研究的目的:
- 调查儿童认知表现在产前母亲炎症和青少年抑郁症状之间关系中的调解作用.
主要方法:
- 从儿童健康和发育研究 (CHDS) 队列中检查了696个母子双.
- 测试的母体血清炎症生物标志物 (IL-6,IL-8,IL-1RA,sTNF-RII) 来自第一和第二个三个月.
- 使用皮博迪图片词汇测试 (PPVT) 评估儿童的认知表现 (9-11岁) 和青少年的抑郁症状 (15-17岁) 通过自我报告.
主要成果:
- 第二季度较高的IL-1RA与较低的儿童PPVT得分有关.
- 较低的儿童PPVT得分显著预测了更高的青少年抑郁症状.
- 发现第二季度IL-1RA对青少年抑郁症状有显著的间接影响,其介于儿童PPVT得分.
结论:
- 儿童的认知表现,特别是感受性词汇,可能充当将产前母亲炎症与青少年抑郁症联系起来的调解者.
- 儿童认知能力下降是导致青少年在产前炎症后抑郁症风险增加的潜在机制.
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