相关实验视频

Updated: Jun 26, 2025

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

在多发性硬化和抑郁症中同时发生与炎症相关的大脑重组

Lara S Molina Galindo¹, Gabriel Gonzalez-Escamilla¹, Vinzenz Fleischer¹

¹Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine-Main Neuroscience Network (rmn(2)), University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.

Brain, behavior, and immunity

|May 18, 2024

概括

大型抑郁症 (MDD) 和多发性硬化症 (MS) 中的神经炎症显示出类似的大脑网络变化. 灰白质对比 (GWc) 核磁共振显示大脑连接的改变,这可能表明这两种情况都有共同的炎症过程.

科学领域:

神经成像是一种神经成像.
神经炎症是一种神经炎症.
精神病学是一个精神病学.
神经学神经学

背景情况:

神经炎症与多发性硬化症 (MS) 和严重抑郁症 (MDD) 有关.
先进的磁共振成像 (MRI) 在检测MDD和MS灰色至白色物质边界的神经炎症活动中的作用尚不清楚.

研究的目的:

调查灰白质对比 (GWc) MRI特征是否可以作为MDD和MS中神经炎症活性的代理.
用GWc衍生的连接来分析MDD和MS患者的结构网络变化.

主要方法:

包括684名参与者:MDD患者 (复发和单次发作),MS患者 (有或没有抑郁症状) 和健康对照.
使用3T-T1wMRI推导GWc并表征GWc共变网络 (模块化,集群系数,程度).
采用支向量机来评估GWc根据抑郁症严重程度 (BDI) 对群体分层的能力.

主要成果:

与健康对照组相比,MDD和MS患者的网络模块化和集群性增加.
从健康对照组观察到MS患者 (有/没有抑郁症) 和MDD患者 (单次/反复发作) 的模块性增加的梯度.
降低GWc与抑郁症状增加相关,并且与患者群体的抑郁症得分有显著的关联. 在MS中,抑郁症状的分类准确率为88%.

结论:

通过GWc分析检测到的结构网络变化在MDD和MS中是相似的,这表明常见的潜在炎症事件如脱髓化和神经炎症.
这些变化似乎随着症状的严重程度而变化.
在MS中,GWc分析可能有助于阐明伴随性抑郁症的发生.

关键词:

皮层形态计量共变度的皮层形态计量共变度.皮层形态测量是指皮层形态测量.灰色到白色物质的结合点.大型抑郁症主要是抑郁症.多发性硬化症是多发性硬化症.网络重组网络重组

更多相关视频

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Published on: May 19, 2020

相关概念视频

Stress and Mental Health

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...

Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...