自我报告和生理压力的作用在nocebo过敏症中的作用
A Skvortsova1, S H Meeuwis1, S Derksen1
1Health, Medical and Neuropsychology unit, Faculty of Social and Behavioural Sciences, Leiden University, the Netherlands.
Biological psychology
|May 18, 2024
概括
社会压力不会直接增加nocebo过敏症,但压力引起的焦虑增加可以放大疼痛敏感度. 减少焦虑可能有助于缓解临床环境中的nocebo效应.
科学领域:
- 心理神经免疫学 心理神经免疫学
- 疼痛感知 疼痛感知
- 压力生理学 压力生理学
背景情况:
- 负面的期望可以增加疼痛敏感性,这种现象被称为nocebo过敏症.
- 影响nocebo过敏症的潜在生理和心理因素仍然不完全理解.
- 研究社会压力因素对nocebo效应的影响对于理解疼痛调节至关重要.
研究的目的:
- 为了确定社会压力是否会影响nocebo过敏症.
- 检查自我报告和生理压力反应是否调解了社会压力和nocebo过敏症之间的关系.
- 探索焦虑和压力标志物的作用在nocebo效应的背景下.
主要方法:
- 招募了52名健康参与者,随机分配给特里尔社会压力测试 (TSST) 或对照条件.
- 使用负面暗示和疼痛调节范式诱导的nocebo过敏症.
- 评估自我报告的焦虑/压力和生理标志物 (皮质醇,α-氨酶,心率,皮肤导电性) 作为应对压力的反应.
主要成果:
- 压力和对照组都表现出显著的nocebo过敏症.
- 与对照组相比,压力组表现出高度的焦虑,自我报告的压力和皮质醇水平.
- 两组之间没有观察到nocebo过敏症的大小的显著差异;焦虑部分介导了压力效应.
结论:
- 外部社会压力因素不会直接改变nocebo过敏症的大小.
- 增加焦虑,由社会压力引发,可以增强nocebo过敏症.
- 旨在减少与压力相关的焦虑的临床策略可能会减轻nocebo效应.
相关概念视频
Nociception
27.9K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
27.9K
Hypothalamic-Pituitary Axis
59.9K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
59.9K
Physiological Foundation of Stress
56
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Role of the Sympathetic Nervous System
Adrenaline triggers the...
56
The Placebo Effect
6.1K
The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
6.1K
Psychological Responses to Stress
54
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
54
Introduction to Stress and Lifestyle
104
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
104


