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肠道微生物组与血压和血细胞计数之间的遗传关联作为媒介:双步门德尔随机化分析
Jiyu Zhang1, Junyi He1, Yuhan Liao1
1Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China; Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China; Hubei Engineering Research Center for Immunological Diagnosis and Therapy of Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China.
肠道细菌通过改变血细胞计数来影响血压. 这项研究揭示了红细胞,淋巴细胞和血小板数量调解肠道微生物群.
科学领域:
- 遗传学 是一个遗传学.
- 微生物学 微生物学
- 心血管健康 心血管健康
背景情况:
- 在肠道微生物群和高血压之间确立了遗传联系.
- 血液细胞计数在这种关系中的调解作用尚未被探索.
研究的目的:
- 研究将肠道微生物组,周围血液细胞计数和血压联系在一起的遗传关联和因果关系.
- 探索血液细胞计数在肠道微生物群-高血压轴中的调解作用.
主要方法:
- 两个样本调解 门德尔随机化分析使用全基因组关联研究总结统计数据.
- 逆方差加权 (IVW) 方法作为主要分析,MR Egger,加权中位数,简单模式和加权模式作为补充方法.
- 通过全面的灵敏度分析来确保稳定性.
主要成果:
- 发现了14种微生物种群与腹压血压 (DBP),15种与静脉压血压 (SBP) 之间存在显著的关联.
- 红细胞计数,淋巴细胞计数和血小板计数被确定为调解因素.
- 确定了特定的介导途径:白菌通过红细胞计数 (8.262%),Subdoligranulum和Collinsella通过淋巴细胞计数 (2.642%,2.749%) 到SBP,Eubacterium心室菌群通过血小板计数 (3.421%) 到SBP.
结论:
- 肠道微生物群通过调节血细胞计数对血压产生因果影响.
- 这些发现为高血压病原性提供了新的见解.
- 针对肠道微生物群-血细胞计数-血压轴的临床干预的潜力.
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