相关实验视频

Updated: Jun 26, 2025

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on: May 9, 2025

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在ENSITRELVIR结合和SARS-CoV-2主要蛋白质酶的短暂二元化过程中可视化活性位点氧化离子环过渡

Andrey Kovalevsky1, Annie Aniana2, Leighton Coates3

  • 1Neutron Scattering Division, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, TN, 37831, USA.

Journal of molecular biology
|May 18, 2024
PubMed
概括

在SARS-CoV-2主要蛋白酶 (MPro) 需要N-终端二分化活动. 恩西特里尔维尔 (ESV) 结合揭示了二分化关键残留物,并捕获了活性部位.

关键词:
在SARS CoV-2的主要蛋白酶.恩西特里尔维尔结合剂一个单质二质的平衡状态.氧离子环形态的构成在室温的X射线晶体学.

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