在一个心脏中心发生了三起Cutibacterium avidum假感染性内心炎的病例
Niels Nørskov-Lauritsen1, Lars P S Riber2, Esad Dzajic3
1Department of Clinical Microbiology, Odense University Hospital, Odense, Denmark.
概括
Cutibacterium avidum假内心炎是罕见的,但难以检测. 这项研究调查了一个集群,发现细菌难以培养,这表明在培养负的病例中可能报告不足.
科学领域:
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
- 微生物学 微生物学
背景情况:
- 假感染性内心炎 (IE) 是心脏手术后的一种严重并发症.
- Cutibacterium avidum (C. avidum) 是IE中新出现的病原体,特别是在动脉置换后.
- 一个不寻常的C. avidum IE病例集群促使了这项调查.
研究的目的:
- 为了研究C. avidum假体 IE在单个心脏中心的异常聚类.
- 在术后IE中确定C. avidum的潜在来源和传播途径.
- 改进C. avidum IE的诊断方法.
主要方法:
- 在21个月的时间内进行大动脉置换后,对3名患有C. avidum细菌病的患者进行了回顾性分析.
- 对操作程序和抗菌素处方的审查.
- 细菌分离的全基因组测序,以评估遗传相关性.
主要成果:
- 这三名患者在大动脉置换后24-128天内出现了C. avidum细菌病.
- 不同的手术团队植入了假体门,排除了一个单一的手术团队作为来源.
- 全基因组测序确定了一个独特的C. avidum亚群,但没有表明患者对患者的传播.
结论:
- 在假牙内心炎中检测C. avidum可能具有挑战性,血液培养和PCR的结果不一致.
- C. avidum可能是培养负的假内心炎的不足报告的原因.
- 在培养负的假内心炎病例中,建议对C. avidum进行仔细检查.
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