劳伊诺伊德A-X:来自Croton lauiui的具有抗炎活性的拉巴丹类型的迪特尔佩诺伊德
Zong-Yi Zhang1, Ying Li2, Jin-Hai Yu2
1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, People's Republic of China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, People's Republic of China.
Phytochemistry
|May 18, 2024
概括
这项研究从传统中医药Croton laui中分离出了24种新的拉巴丹二烯酸. 化合物18和28通过抑制巨细胞中氧化的产生,显示出显著的抗炎作用.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
- 药用植物研究 药用植物研究
背景情况:
- 克罗顿 (Euphorbiaceae) 传统上被中国的李族人用于各种疾病.
- 了解C. laui的化学成分可以阐明其药用特性.
研究的目的:
- 为了研究来自C. laui树皮的labdane diterpenoids的化学多样性.
- 为了识别具有潜在药理活动的化合物.
主要方法:
- 乙醇树皮提取物的广泛色谱隔离.
- 使用光谱分析 (NMR,ECD) 和X射线衍射的结构阐明.
- 在RAW 264.7巨细胞中通过氧化抑制试验评估抗炎活性.
主要成果:
- 已分离出24种新型拉巴丹二烯酸 (劳酸A-X) 和5种已知的类似物.
- 化合物1-3具有一个独特的11(12→13)-abeo-16-nor-labdane骨架.
- 化合物11和12代表一种罕见的14,15-dinor-labdane diterpenoids类.
- 化合物18和28显著抑制了氧化的产生 (IC50值分别为3.37微米和5.82微米).
结论:
- 这项研究显著扩大了来自C. laui. laui. 的拉巴丹二类的已知化学多样性.
- 隔离的化合物,特别是18和28,显示出有前途的抗炎作用.
- 这些发现为进一步研究C. laui.ui的民族医学应用提供了基础.
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