作为抗抑郁药治疗反应的预测指标的外周血清激素水平:一个系统性审查
Amanda Holck1, Pouya Movahed2, Åsa Westrin3
1Unit for Biological and Precision Psychiatry, Department of Clinical Sciences Lund, Lund University, Lund, Sweden; Psychiatric Clinic Lund, Lund, Sweden.
概括
周围血液中的血清素 (5-基三胺) 显示出作为抗抑郁药反应的生物标志物的潜力. 虽然没有得到确定的证据,但较高的基线水平可能预测SSRI的更好的结果,这需要进一步研究.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 生物标志物研究 生物标志物研究
背景情况:
- 目前缺乏可靠的生物标志物来预测抑郁症疾病中抗抑郁药治疗反应.
- 外周血液中的5-二三胺 (血清素) 已被提议作为治疗疗效的潜在生物标志物.
- 需要系统地评估现有的关于外周血清素作为生物标志物的科学证据.
研究的目的:
- 系统地审查和评估对外围血液中的5-基三胺作为抗抑郁药物治疗反应的生物标志物的科学证据.
- 评估基线外围5-HT水平与抗抑郁药物的临床反应之间的关联.
- 研究SSRI治疗对外围5-HT水平的影响及其与治疗结果的相关性.
主要方法:
- 在主要数据库中进行系统的文献搜索:MEDLINE,Embase,PsycINFO和Cochrane控制试验中央注册表.
- 包括26项相关研究,调查外围5-HT作为抗抑郁药治疗的生物标志物.
- 分析研究以确定基线5-HT水平与治疗反应之间的关联,以及治疗后5-HT水平的变化.
主要成果:
- 总的来说,在基线外围5-HT和一般抗抑郁药治疗反应之间没有一致的关联,没有强有力的支持.
- 几项较大,偏差风险较低的研究表明,较高的基线5-HT水平可能与对SSRI的更大反应有关.
- 证实SSRI治疗与外围5-HT水平的降低有关,但这种降低的大小和更好的治疗结果之间的联系是不确定的.
结论:
- 外围5-HT作为抗抑郁药反应可靠生物标志物的假设需要进一步调查,特别是关注SSRI.
- 较高的基线外周5-HT可能作为SSRI疗效的预测生物标志物,值得未来研究.
- 虽然SSRI治疗减少了外围5-HT,但其在预测治疗成功中的作用仍然不确定.
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