喷雾冷干燥的大麻素与二聚酸胆 (DPPC) 进行吸入和提高溶解度
Waiting Tai1, Jonathon Carl Arnold2, Hak-Kim Chan1
1Advanced Drug Delivery Group, Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, NSW 2006, Australia.
International journal of pharmaceutics
|May 18, 2024
概括
吸入式大麻 (CBD) 粉末是使用喷雾冷干燥制造的. 添加DPPC显著改善了CBD溶解度和气溶在肺部药物输送中的性能.
科学领域:
- 制药科学 制药科学
- 药物运输 药物运输 药物运输
- 材料科学 材料科学 材料科学
背景情况:
- 肺部输送为大麻 (CBD) 等药物提供了高生物可用性和快速作用.
- 对于CBD肺部输送的一个关键挑战是其在水中的溶解性差.
- 开发稳定,可吸入的CBD配方对于有效的治疗用途至关重要.
研究的目的:
- 为了创建可吸入的大麻 (CBD) 粉末,提高溶解度.
- 为了描述这些CBD粉末的固态特性.
- 评估这些配方在肺部药物输送方面的潜力.
主要方法:
- 大麻素 (CBD) 是用曼尼托尔或三二酸盐喷雾干的,含有或不含双基酸胆 (DPPC).
- 分析了固态特性,包括晶度和残留溶剂水平.
- 评估了粒子大小,形态,可溶性和气溶性能.
主要成果:
- 所有喷雾冷干燥粉末都表现出高产量 (>70%) 的多孔,球形颗粒.
- 添加二巴米酸胆 (DPPC) 增加了CBD的溶解度,从0.36μg/mL增加到超过2μg/mL.
- 含DPPC的配方显示了提高的气溶性能,从RS01吸入器中,细颗粒物分数为34-43%.
结论:
- 喷雾冷干燥对于生产具有增强溶解性的可吸入CBD粉末是有效的.
- 双巴胺基酸胆 (DPPC) 是一种有益的辅助剂,可以改善CBD的溶解性和空气化.
- 这些配方代表了吸入CBD和其他大麻素的有希望的平台.
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