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Updated: Jun 26, 2025

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
07:44

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

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与瘤相关的巨细胞通过PKM2二分体-STAT3复杂核转位增强了PD-L1介导的膀癌的免疫逃逸

Yongbo Yu1, Ye Liang2, Fei Xie2

  • 1Urology Department, The Affiliated Hospital of Qingdao University, China; Key Laboratory, Department of Urology and Andrology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China; Medicine College, Qingdao University, Qingdao, China; Department of Urology, Weifang People's Hospital, Weifang Medical University, Weifang, China.

Cancer letters
|May 18, 2024
PubMed
概括

M2-TAMs分泌TGF-β,通过PKM2和PD-L1.1促进膀癌的免疫逃避. 阻断TGF-β和PKM2增强了抗瘤免疫力,为膀癌提供了一个新的治疗策略.

关键词:
膀癌是一种癌症.组合免疫疗法是一种联合免疫疗法.在PD-L1中.在TGF-β的基础上.与瘤相关的巨细胞.

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