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腹腔皮GABA和谷氨酸神经元通过明显调节VTA细胞类型来驱动接近和避免

Lauren Faget^1,2, Lucie Oriol³, Wen-Chun Lee³

¹Department of Neurosciences, University of California San Diego, La Jolla, CA, USA. lfaget@health.ucsd.edu.

Nature communications

|May 18, 2024

概括

腹部皮体 (VP) 使用GABA和谷氨酸神经元通过调节腹部体区域 (VTA) 活动来控制接近和回避行为. 对VTA的VP神经元刺激效应是行为依赖的,突出显示了复杂的神经电路调节.

科学领域:

神经科学是一个神经科学.
行为神经科学行为神经科学
神经生物学神经生物学神经生物学

背景情况:

腹皮 (VP) 投射到腹膜区域 (VTA),影响接近和避开行为.
通过VP细胞类型调节VTA活动和随后的行为,精确的机制仍然在很大程度上未被探索.

研究的目的:

调查不同的VP GABA和谷氨酸神经元群是如何塑造VTA活动和驱动有动力的行为.
阐明VP投射在神经电路中所起的作用,即奖励方法和厌恶回避的基础.

主要方法:

在接近奖励或厌恶刺激交付时,VP GABA和谷氨酸神经元的激活.
在VTA中进行电生理记录,以评估在VP刺激后的神经元活动.
行为测试评估VP神经元刺激对接近和回避的影响.
在核 (NAc) 亚区域中测量多巴胺释放量.

主要成果:

无论是VP GABA和谷氨酸神经元都是通过奖励方法或厌恶刺激来激活的.
VP GABA神经元刺激抑制了VTA GABA神经元,但激活了VTA多巴胺和谷氨酸神经元,与行为依赖的VTA招募.
VP谷氨酸神经元刺激激活了VTAGABA,多巴胺和谷氨酸神经元,驱动厌恶和差异调节NAc亚区中的多巴胺释放.

结论:

异质的VP投射到VTA不同调节VTA神经元活动.
通过对VTA电路的调制,VP细胞类型在塑造接近和避开行为方面发挥着不同的作用.
VP投影通过影响特定的NAc通路中的多巴胺信号传递,有助于激发行为.

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