童年逆境,加速的灰色年龄,以及相关的健康后果
Zachary M Harvanek1,2, Anastacia Y Kudinova3,4, Samantha A Wong5
1Department of Psychiatry, Yale University, New Haven, CT, USA. Zachary.Harvanek@Yale.edu.
Journal of behavioral medicine
|May 18, 2024
概括
童年逆境与加速表观遗传衰老和较差的代谢健康有关,包括肥胖和胰岛素抵抗. 这些影响在较高的身体质量指数 (BMI) 水平上尤其明显,突出了早期生活压力和长期健康结果之间的相互作用.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 代谢健康 代谢健康
- 心理学 心理学 心理学
背景情况:
- 童年逆境是已知的成人健康问题风险因素,包括肥胖和心脏代谢疾病.
- 表观遗传变化,如表观遗传衰老,是将早期生活压力与持续的健康影响联系起来的机制.
- 心脏代谢健康的个体变化可能受到表观遗传因素的影响,即使在具有相似体重指数 (BMI) 的个体中也是如此.
研究的目的:
- 在两个独立的成年人群中调查童年逆境,表观遗传衰老和代谢健康之间的关联.
- 检查特定类型的童年逆境 (如虐待,忽视) 和它们与表观遗传衰老的关系.
- 探索BMI在表观遗传衰老和胰岛素抵抗之间的关联中起的缓解作用.
主要方法:
- 评估两个独立的成年人横截面队列 (n=195和n=477).
- 使用二分法分类和童年创伤问卷 (CTQ) 评估童年逆境.
- 使用 GrimAge Acceleration (GAA) 测量表观遗传衰老,并分析CTQ得分,BMI和胰岛素抵抗的相关性.
主要成果:
- 在这两组人群中,童年逆境与增加的灰色年龄加速 (GAA) 有显著的关联.
- 身体和性虐待CTQ的子尺度与增加的GAA有关,而忽视则没有.
- 较高的CTQ得分与较高的BMI和两个队列中的胰岛素抵抗增加相关.
- 体重指数调节了GAA和胰岛素抵抗之间的关系,这种关联仅在较高的体重指数时才显著.
结论:
- 童年逆境与表观遗传衰老加速和不良的代谢健康标志物有关,包括肥胖和胰岛素抵抗.
- 表观遗传衰老,特别是在更高的BMI的背景下,可能会调解早期生活压力的长期健康后果.
- 这些发现强调了了解早期生活经验,表观遗传修饰和代谢健康之间的相互作用对于长期福祉的重要性.
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