通过孟德尔随机化分析确定了瘤的潜在药物标
Na Song1,2, Pingyu Shi2, Kai Cui2
1Department of Pathology, Xinxiang Key Laboratory of Precision Medicine, The First Affiliated Hospital of Xinxiang Medical University, Jiankang Road No.88, Xinxiang, 453100, China.
Scientific reports
|May 18, 2024
概括
这项研究确定了四种蛋白质S100A14,S100A16,PDE5A和MIA作为癌症潜在的药物标. 这些蛋白与HER阳性乳腺癌,结直肠癌和非小细胞肺癌的风险有关,为癌症预防和治疗提供了新的途径.
科学领域:
- 遗传学 是一个遗传学.
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 癌症发病率和死亡率仍然很高,现有治疗方法的疗效不足.
- 对于有效的癌症预防和治疗,有必要确定新的药物标和生物标志物.
- 评估人类蛋白质与癌症风险及其作为治疗点的潜在因果关系.
研究的目的:
- 通过使用遗传数据,研究人类蛋白质与9种主要癌症类型的风险之间的因果关系.
- 为了确定潜在的蛋白质生物标志物和药物点乳腺,结直肠,肺,肝脏,膀,前列腺,脏,头和胰腺癌.
- 用孟德尔随机化,外部队列和药物数据库验证发现.
主要方法:
- 孟德尔随机化 (MR) 分析使用来自FinnGen和cis-protein定量特征位点 (cis-pQTL) 数据的总结统计数据.
- 探索潜在药物点和九种癌症类型之间的关联.
- 通过双向MR,施泰格过,同地化分析和DrugBank数据库进行验证.
主要成果:
- S100A16被确定为保护性蛋白,S100A14被确定为HER阳性乳腺癌的风险蛋白 (FDR <0.05).
- 二酶5A (PDE5A) 被确定为结直肠癌 (CRC) 的风险蛋白.
- 被确定为非小细胞肺癌 (NSCLC) 的保护性蛋白质的黑色素瘤抑制活性 (MIA).
- 定位分析证实了S100A14的共同因果变异,HER阳性乳腺癌的S100A16和CRC的PDE5A.
结论:
- 循环中的S100A14和S100A16与分别增加和降低HER阳性乳腺癌的风险有关.
- 循环PDE5A与CRC风险增加有关,而MIA与NSCLC风险降低有关.
- 这四种蛋白质 (S100A14,S100A16,PDE5A,MIA) 代表了癌症预防的有前途的生物标志物和治疗开发的潜在药物标.
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