在患有myxomatous中膜疾病的狗中分析铁的参数
Ewa Kumiega1, Kamil A Kobak2, Agnieszka Noszczyk-Nowak3
1Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Grunwaldzki sq 47, Wrocław, 50-366, Poland. ewa.kumiega@upwr.edu.pl.
BMC veterinary research
|May 18, 2024
概括
血清中的铁缺乏标志物在患有肌肉膜病 (MMVD) 的狗中没有显著差异. 然而,心力衰竭 (HF) 狗的网细胞百分比增加,与MMVD严重程度相关.
科学领域:
- 兽医心脏病学 兽医心脏病学
- 狗内科 狗内科 狗内科
- 心血管研究研究心血管研究
背景情况:
- 肌肉膜病 (MMVD) 是小型品种狗中最常见的获得性心血管疾病.
- 与人类心力衰竭 (HF) 患者不同的是,MMVD的狗中缺铁 (ID) 的患病率尚未得到充分确立.
- 在MMVD的狗中早期发现ID对于了解疾病进展至关重要.
研究的目的:
- 评估血清缺铁标志物和全血网状细胞参数在MMVD的狗中早期检测ID的实用性.
- 在MMVD不同阶段的狗中,将ID标记与心声学和生物化学参数相关联.
主要方法:
- 包括68只患有MMVD的狗 (B1,B2,C,D阶段) 和12只健康的对照.
- 血清铁的分析,转林和度 (SAT),不和铁结合能力 (UIBC),总铁结合能力 (TIBC),费里丁和可溶性转林受体.
- 手动评估网细胞百分比和与心声回声指数的相关性 (LA/Ao,LVIDdN).
主要成果:
- 血清铁度在12.5%的MMVD狗中低于参考范围.
- %SAT,UIBC和TIBC在MMVD组和对照组之间没有显著差异.
- 与对照组相比,在有症状的HF狗中观察到显著增加的网细胞百分比 (p=0.027).
- 在ID参数,心声回声指数 (LA/Ao,LVIDdN) 和生化参数之间发现了积极的相关性,表明与MMVD严重程度的联系.
结论:
- 单独的血清ID标记在MMVD的狗中与健康对照相比没有显著差异.
- 网细胞百分比可以作为MMVD狗早期ID的更敏感的指标,特别是在后期阶段.
- ID参数与心脏结构变化之间的相关性突出显示了MMVD的系统影响.
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