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Updated: Jun 26, 2025

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一个数学模型用于多次感染的HIV动态:对免疫逃脱的含义

Qi Deng1,2, Ting Guo3, Zhipeng Qiu1

  • 1School of Mathematics and Statistics, Nanjing University of Science and Technology, Nanjing, 210094, People's Republic of China.

Journal of mathematical biology
|May 19, 2024
PubMed
概括

多重感染影响病毒竞争和多样性. 数学建模显示,虽然病毒动态在感染多重性中是相似的,但四重感染加剧了菌株竞争,影响了治疗结果.

关键词:
细胞毒性T淋巴细胞艾滋病病毒 艾滋病病毒 艾滋病病毒免疫逃脱是为了逃脱免疫.多种感染多种感染.

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Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
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