通过使用Shapley值,从机器学习中调查血液输血对COVID-19的影响
Behzad Einollahi1, Mohammad Javanbakht2, Mehrdad Ebrahimi2
1Nephrology and Urology Research Center, Clinical Science Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. behzad.einollahi@gmail.com.
Inflammopharmacology
|May 19, 2024
概括
血液输血 (HP) 通过减少通风需求和死亡率,显著改善了严重COVID-19患者的治疗结果. 这种体外治疗有效过血液,对患者的生存和预后产生积极影响.
科学领域:
- 身体外疗法 身体外疗法
- 关键护理医学 关键护理医学
- 免疫调节是一种免疫调节.
背景情况:
- 严重的COVID-19的特征是细胞因子风暴,导致器官损伤.
- 血液输血 (HP) 是一种外体疗法,旨在从血液中去除炎症媒介.
- 在严重的COVID-19中评估HP的临床疗效对于改善患者结果至关重要.
研究的目的:
- 评估在重症COVID-19患者中血液输血 (HP) 的临床益处.
- 为了比较标准护理治疗的患者与标准护理加HP治疗的患者的结果.
- 利用机器学习,特别是Shapley值,了解HP对患者预后的贡献.
主要方法:
- 这是一项对578名患有严重COVID-19的住院患者进行的回顾性队列研究.
- 对照组接受了标准的皮质类固醇治疗 (I方案).
- 惠普组接受了标准的皮质类固醇治疗加上使用Cytosorb H300 (方案II) 的血液输血,会议频率基于胸部CT发现. 机器学习模型结合了患者的特征,药物和临床条件来计算Shapley值.
主要成果:
- 与对照组相比,血液输血 (HP) 组显示出有利的临床反应.
- 一到三次HP会话减少了严重COVID-19患者的通风需求和死亡率.
- 与对照组相比,HP与炎症标志物 (费里丁),肌素,D-二次体和WBC水平的显著降低有关. 在使用不同类型的药物之间观察到显著的差异 (P<0.05).
结论:
- 血液输血是预测严重COVID-19患者存活率的一个重要因素.
- 惠普在减少炎症和改善功能标志物方面表现出积极影响.
- 该研究强调了HP作为严重COVID-19病例的治疗选择的关键作用,影响了患者的预后.
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