早期与晚期卵泡期卵巢刺激:一个随机对照试验
Sylvie De Rijdt1, Kim Illingworth1, Neelke De Munck1
1Brussels IVF, Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Jette, Belgium.
Reproductive biomedicine online
|May 19, 2024
概括
在较晚的卵泡阶段开始卵巢刺激与使用性腺激素释放激素 (GnRH) 抗剂协议的卵细胞捐赠者早期阶段一样有效. 这种方法还可以降低药物成本和刺激的持续时间.
科学领域:
- 生殖内分泌学和不孕症治疗.
- 卵子捐献的卵巢刺激协议.
背景情况:
- 卵子捐赠需要有效的卵巢刺激协议来最大限度地提高卵子产量.
- 激素释放激素 (GnRH) 抗剂方案中启动刺激的时间可能会影响效率和成本.
研究的目的:
- 为了比较晚期卵泡阶段与早期卵泡阶段刺激在卵细胞捐赠者的效率.
- 评估刺激时间对卵细胞产量,药物使用和成本在GnRH抗剂协议中的影响.
主要方法:
- 这是一项开放的,第三阶段,随机对照试验,涉及84名卵细胞捐赠者.
- 两只手臂:早期的卵泡开始 (对照) 和晚期的卵泡开始 (研究),使用复合FSH (r-FSH) 225 IU.
- 主要结局:获取的卵细胞数量;次要结局:成熟的卵细胞,药物消耗和成本.
主要成果:
- 在早期 (15.5 ± 11.0) 和晚期 (14.0 ± 10.7) 毛囊期刺激组之间,检索出的卵细胞数量没有显著差异.
- 较晚的卵泡期组表现出更短的刺激持续时间和更低的总r-FSH消耗.
- 对于毛囊后期阶段组,每个周期的药物成本显著降低 (€1147.9 ± 182.8 与€979.9 ± 129.0 相比).
结论:
- 晚期卵泡阶段刺激与早期卵泡阶段刺激相比,在GnRH对抗剂协议中的卵细胞产量没有劣势.
- 在较晚的卵泡阶段启动刺激,在减少刺激持续时间,药物使用和整体成本方面提供了潜在的好处.
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