使用手机应用程序 (PRODEMOS) 预防痴呆症:一个跨国,随机,受控的有效性实施试验
Eric P Moll van Charante1, Marieke P Hoevenaar-Blom1, Manshu Song2
1Department of General Practice, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands; Department of Public and Occupational Health, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
The lancet. Healthy longevity
|May 19, 2024
概括
一项移动卫生干预措施适度降低了服务不足人群中痴呆症风险因素. 虽然实施面临挑战,但参与者积极参与,显示未来痴呆症预防策略的希望.
科学领域:
- 公共卫生 公共卫生
- 老年学是一门学科.
- 数字健康数字健康
背景情况:
- 痴呆症的患病率在全球范围内不断上升,不成比例地影响低收入国家和低社会经济地位的个人.
- 服务不足的人群面临着更高的痴呆风险因素负担.
- 移动健康 (mHealth) 干预措施为接触高风险群体提供了一个潜在的解决方案.
研究的目的:
- 调查辅导员支持的移动健康干预措施在减少痴呆症风险因素方面的有效性.
- 评估在不同人群中实施移动健康干预的成果.
- 评估干预对心血管风险因素,衰老和痴呆风险评分 (CAIDE) 的影响.
主要方法:
- 一个开放的标签,盲目的终点,混合有效性-实施随机对照试验 (RCT).
- 55-75岁的参与者,至少有两个痴呆风险因素,从英国 (社会经济地位低) 和中国招募.
- 主要结果是CAIDE风险评分在12-18个月内发生的变化,对实施结果的混合方法评估.
主要成果:
- 与对照组相比,干预组的CAIDE平均得分 (-0.16分) 略有改善 (-0.01分).
- 81%的干预参与者接受了干预,50%的人保持了积极参与.
- 干预被认为是适当和可接受的,具有良好的忠诚度和可行性,成本低.
结论:
- 辅导员支持的移动健康干预在减少目标人群中痴呆风险因素方面表现出适度的有效性.
- 存在实施挑战,但可以通过积极参与者的参与来克服.
- 需要进一步的大规模RCT,随访时间更长,以确认认知能力下降和痴呆症减少.
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