COMT变种与乳房和乳头疼痛有关
Tumilara Aderibigbe1, Shannon L Kelleher2, Wendy A Henderson3
1School of Nursing, University of Connecticut, Storrs, Connecticut.
The journal of pain
|May 19, 2024
概括
母亲遗传学会影响母乳养的成功. 甲基转移酶 (COMT) 基因的特定变异与增加的乳房和乳头疼痛有关,可能会影响纯母乳养率.
科学领域:
- 遗传学 是一个遗传学.
- 生殖健康 生殖健康
- 疼痛研究 疼痛研究
背景情况:
- 纯母乳养提供了显著的健康益处,但率仍然很低,乳房/乳头疼痛是主要障碍.
- 虽然环境因素是公认的,但母乳遗传在母乳养结果,特别是疼痛方面的作用尚未得到充分探索.
- 了解遗传倾向可以为支持母乳养的母亲提供新的见解.
研究的目的:
- 调查与哺乳相关基因的遗传变异与纯母乳养决定因素之间的关联.
- 在像PRLR,OXTR,COMT和MFGE8这样的基因中识别特定的单核酸多态 (SNP),这些基因可能会影响母乳养疼痛和结果.
主要方法:
- 一项涉及哺乳妇女的随机对照试验 (NCT05262920) 的二次分析.
- 在四个候选基因中检查了SNP:PRLR,OXTR,COMT和MFGE8.
- 评估了乳房/乳头疼痛,感觉到奶量不足,并使用经过验证的量表来评估母乳养的自我有效性.
主要成果:
- 在Catechol-O-methyltransferase (COMT) 基因中的单核酸多态 (SNPs) 显示出与母乳养相关结果的显著关联.
- 对于COMT rs4633和rs4680的小等位基因 (T,A) 携带者,与主要等位基因同胞 (C,G) 相比,报告乳房和乳头疼痛强度增加.
- 这项研究是第一个将COMT基因变异与乳房/乳头疼痛及其对母乳养专属性的潜在影响联系起来的研究.
结论:
- 在COMT基因,特别是rs4633和rs4680中的遗传变异与母亲的乳房和乳头疼痛有关.
- 这些发现表明,在母乳养期间影响疼痛感知的一种遗传成分,这可能会影响母亲完全母乳养的能力.
- 有针对性的基因查可能会识别患有疼痛风险较高的女性,从而实现主动支持策略.
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