饮食缺乏导致小的心脏炎症损伤
Shu Yun Ji1, Zhen Chen Yin1, Chun Lai Ma1
1College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
The Journal of nutrition
|May 19, 2024
概括
年轻的卵型小中饮食缺乏会导致心脏炎症和损伤. 这是由减少的蛋白表达驱动的,导致氧化应激和炎症途径的激活.
科学领域:
- 动物营养 动物营养
- 心血管生理学心血管生理学
- 细胞生物学 细胞生物学
背景情况:
- 产母的新陈代谢率很高,因此容易患心脏病.
- 之前的研究将缺乏与 brojler chickens 的心脏疾病联系在一起.
研究的目的:
- 为了研究缺乏的饮食对年轻卵型小的心脏损伤的影响.
- 阐明缺乏引起的心脏损伤的潜在机制.
主要方法:
- 白色莱戈恩小被食35天,要么是缺乏的基础饮食,要么是补充饮食.
- 分析心脏组织的组织结构,含量,蛋白表达,抗氧化状态和炎症标志物.
- 这项研究研究了托尔类受体4/细胞外信号调节激酶/p38地图激酶/c-Jun N-终端激酶 (TLR4/ERK/P38/JNK) 途径.
主要成果:
- 养低饮食的小体重和心脏水平较低.
- 观察到心脏炎症,高氧化应激标志物 (甲,活性氧物种) 和减少的谷氨.
- 发炎媒介的表达增加,包括细胞因子和化学因子,以及TLR4/ERK/P38/JNK通路的激活.
结论:
- 饮食中的不足会触发卵型小的心脏中的单核炎症细胞透.
- 这种心脏损伤与蛋白功能下降,氧化应激增加以及随后TLR4和NF-κB通路的激活有关.
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