修改了滚筒紧缩模型,以考虑滚筒速度对干颗粒处理过程中粉末紧缩的影响
Indu Muthancheri1, Mario Rousselin2, Anna Espinose2
1Process Engineering & Modeling, Sanofi, 350 Water St., 02141, Cambridge, USA.
Journal of pharmaceutical sciences
|May 19, 2024
概括
这项研究增强了滚筒压缩模型,以预测干燥颗粒处理期间的粉末压缩,特别是在高滚筒速度下. 改进的模型通过优化流程和扩展来帮助制药制造.
科学领域:
- 制药工程 制药工程
- 化学工程是化学工程的重要组成部分.
- 材料科学 材料科学 材料科学
背景情况:
- 滚筒压缩对于制药制造中的干颗粒处理至关重要.
- 现有的模型在更高的滚动速度时往往缺乏准确性.
- 了解滚速效应是过程优化的关键.
研究的目的:
- 为了修改苏萨等人. 卷轴压缩模型. 卷轴压缩模型.
- 为了纳入滚动速度对粉末紧缩的影响.
- 为了提高干燥颗粒加工过程的预测准确度.
主要方法:
- 修改过的滚筒压缩模型的文献数据验证.
- 该模型应用于制药配方.
- 与gPROMS集成用于灵敏度分析和设计太空探索.
主要成果:
- 修改后的模型显示了更高的预测准确性,特别是在更高的滚动速度.
- 与文献数据的验证证实了比原始模型更好的性能.
- 在工业制药环境中证明了适用性.
结论:
- 改进的滚筒压缩模型为干燥颗粒处理提供了更好的预测.
- 该模型是制药过程优化和扩展的宝贵工具.
- 为制造环境中的决策提供实用见解.
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