人类测量和癌症预后:一个多中心队列研究
Yue Chen1, Xin Zheng2, Chenan Liu2
1The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, Zhejiang, China; Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China; National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China; Laboratory for Clinical Medicine, Capital Medical University, Beijing, China; Key Laboratory of Cancer FSMP for State Market Regulation, Beijing, China.
The American journal of clinical nutrition
|May 19, 2024
概括
身体尺寸指标,如一般肥胖和手握力低的BMI,显著影响癌症患者的预后. 这些发现为改善癌症护理和患者生存提供了新的见解.
科学领域:
- 在瘤学瘤学.
- 生物统计学 生物统计学
- 人类测量学 人类测量学.
背景情况:
- 人类测量指标与癌症患者的预后有关.
- 个别的人类指数在预测癌症结果方面存在局限性.
研究的目的:
- 评估基于身体大小的七个人类指标在癌症患者预后中的预测作用.
- 为了识别不同的身体尺寸模式及其与癌症存活率的关联.
主要方法:
- 主要成分分析 (PCA) 用于七项测量:身高,体重,BMI,手握力 (HGS),三肌皮折厚度 (TSF),中上臂周长 (MAC) 和小腿周长 (CAC).
- 考克斯回归分析,以评估衍生主要成分 (PC) 与癌症预后之间的关联.
- 进行了子组和灵敏度分析以确认结果的稳定性.
主要成果:
- 确定了四种不同的PC,解释了88.3%的差异.
- PC1 (一般肥胖症) 显示与癌症相关死亡的反向关联 (aHR:0.86;95% CI:0.830.88).
- PC3 (高BMI与低HGS) 和PC4 (高身高与高TSF) 与癌症相关死亡风险增加显著相关 (aHR:1.08;95%CI:1.051.11和aHR:1.05;95%CI:1.021.07).
结论:
- 不同的身体尺寸模式与癌症患者的不同预后结果有关.
- 体重指数的预后影响是由手握力和皮下脂肪调节的.
- 这些发现可能会为提高癌症患者生存率的临床策略提供信息.
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