纳米和微塑料对精子运动的有害影响取决于尺寸
Ziyi Lin1, Zijie Li2, Shuqin Ji2
1The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China; University of Chinese Academy of Sciences, Beijing, China.
Toxicology
|May 19, 2024
概括
微/纳米塑料 (MNP) 暴露会损害精子的运动性,较小的尺寸会引起更明显的影响. 这凸显了解决环境MNP污染的迫切需要,特别是关于较小颗粒的污染.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 生殖生物学 生殖生物学
背景情况:
- 人们越来越担心微/纳米塑料 (MNP) 的生殖毒性,这些塑料在日常生活中暴露.
- 接触MNP通常涉及各种尺寸的异质混合物,而不是单个尺寸.
研究的目的:
- 评估不同微/纳米塑料 (MNP) 尺寸对雄性小鼠生殖参数的影响.
- 调查MNP诱导的生殖毒性的潜在分子机制.
主要方法:
- 使用四个MNP大小范围 (25-30nm,1-5μm,20-27μm,125-150μm) 的口服暴露小鼠模型,在21天的环境相关度下.
- 通过计算机辅助精子分析 (CASA),开放场测试和针对MNP定位的免疫组织化学分析来评估精子运动性.
- 丸转录组分析以确定分子通路的改变.
主要成果:
- 所有测试的MNP大小都影响了精子的运动性,较小的大小 (25-30nm,1-5μm) 显示了最显著的效应.
- 在莱迪格细胞和丸巨细胞中发现了较小的MNP (1-5μm),而在这些组织中没有检测到更大的MNP.
- 转录组分析显示,与精子生成,氧化应激和炎症相关的途径中断,特别是在1-5微米MNP组中.
结论:
- 微/纳米塑料的暴露表明了受体大小影响的精子功能受损.
- 这些发现强调,迫切需要对环境MNP污染进行干预,特别关注较小尺寸的颗粒,因为它们具有明显的影响.
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