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Updated: Apr 13, 2026

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在暴露于特定药品的彩虹鱼中评估急性暴露和生物标志物

C André1, J Auclair1, F Gagné1

  • 1Aquatic Contaminants Research Division, Environment and Climate Change Canada, 105 McGill, Montréal, Québec H2Y 2E7, Canada.

Environmental toxicology and pharmacology
|May 19, 2024
PubMed
概括

废水中的药物有害于水生生物. 这项研究发现,奥兰扎平和特拉佐对彩虹鱼最有毒,毒性与分子重量和疏水性等药物特性有关.

关键词:
生物转化 生物转化发生DNA破裂.年轻的少年.氧化应激是一种氧化应激.药品制造业 药品制造业 药品制造业 药品制造业

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Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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