一个系统的范围审查COVID-19的神经效应
Helena T Hogberg1, Katya Tsaioun2, Joshua D Breidenbach3
1National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA; Evidence-Based Toxicology Collaboration (EBTC), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Neurotoxicology
|May 19, 2024
概括
这项研究回顾了COVID-19的神经症状,发现了诸如厌氧和脑炎之类的常见影响,也发现了诸如神经退行症之类的不那么公认的症状. 报告中的方法改进对于未来的COVID-19病原学的研究是必要的.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 毒理学 毒理学 毒理学
背景情况:
- 由SARS-CoV-2引起的COVID-19流行病与各种神经系统症状有关.
- 该CIAO项目旨在使用不利结果途径 (AOP) 框架来了解COVID-19的病原性.
- 经常在COVID-19患者中观察到诸如厌氧和脑炎之类的神经表现.
研究的目的:
- 系统地审查COVID-19及其神经症状.
- 识别与这些症状相关的关键事件和调节因素.
- 确定了解COVID-19的神经影响的知识差距.
主要方法:
- 进行了系统的范围审查.
- LitCOVID数据库被用于文献检索,最初识别了86,075篇论文.
- 对991项选定的研究进行了全文审查,以进行知识综合.
主要成果:
- 人类观察性研究占主导地位.
- 中期和晚期关键事件/不良结果比早期事件更频繁地报告.
- 发现了不太知名的神经效应,包括脱髓化和认知障碍.
结论:
- 在审查的文献中发现了重要的方法和报告问题.
- 建议在出版摘要中对方法和终点进行更清晰的报告.
- 这些发现可以为COVID-19神经效应的AOP开发提供信息,并强调需要对不太常见的表现形式进行进一步研究.
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