更年期的年龄和与代谢功能障碍相关的脂肪肝疾病的风险:一项为期14年的队列研究
Ehn-Young Kim1, Yae-Ji Lee2, Yu-Jin Kwon3
1Department of Family Medicine, Severance Hospital, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.
概括
经历过过早更年期 (40岁之前) 的女性患代谢功能障碍相关脂肪肝疾病 (MAFLD) 的风险显著增加. 与50岁或更年期进入更年期的女性相比,这种风险更高.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 肝病学 肝病学是一种肝病学.
- 妇女健康 妇女健康
背景情况:
- 更年期涉及雌激素的急剧下降,影响妇女的健康,特别是早期发病.
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是一个越来越令人担忧的健康问题.
研究的目的:
- 检查更年期的年龄与发展MAFLD的风险之间的关系.
- 利用大量的队列和长期跟踪来评估这种关联.
主要方法:
- 分类绝经年龄分为四组:<40 (G1),40-44 (G2),45-49 (G3) 和≥50岁 (G4).
- 采用Cox比例危险回归来分析更年期年龄组的MAFLD发病率.
- 包括1888名参与者,平均随访时间为12.3年.
主要成果:
- 与G4.4相比,在更早的绝经年龄组 (G1-G3) 观察到MAFLD风险增加的趋势.
- 在调整了混因素后,过早更年期组 (G1,<40岁) 的女性与G4 (≥50岁) 组相比,患MAFLD的风险增加了1.40倍.
- 新发性MAFLD的危险比率为1.52 (G1),1.15 (G2) 和1.11 (G3) 与G4,未经调整.
结论:
- 过早更年期 (<40岁) 与患上MAFLD的风险显著增加.
- 经历更年期晚期 (≥50岁) 绝经的女性患MAFLD的风险较低,与过早更年期的女性相比.
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