在口腔前列腺轴上的P. gingivalis通过IL-6/IL-6R通路加剧良性前列腺增生
Shuang-Ying Wang1, Yi Cai1,2, Xiao Hu1,2
1Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Military Medical Research
|May 19, 2024
概括
常见的口腔病原体 Porphyromonas gingivalis 在患有良性前列腺增生 (BPH) 和牙周炎的男性的前列腺液中被发现. 这种感染通过增加炎症和激活Akt通路来促进BPH.
科学领域:
- 口腔微生物学 口腔微生物学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 病变发生学研究 病变发生学研究
背景情况:
- 良性前列腺增生 (BPH) 是老年男性中普遍存在的疾病.
- 牙周炎越来越多地与BPH风险有关,但根本机制尚未完全理解.
- 这项研究调查了P. gingivalis,一个关键的牙周病原体在BPH发展中的作用.
研究的目的:
- 探索 Porphyromonas gingivalis 在良性前列腺增生 (BPH) 的发展中的作用和机制.
- 在患者和动物模型中调查P. gingivalis和BPH之间的关联.
主要方法:
- 从患有牙周炎的BPH患者收集了下斑块和前列腺液,用于16S rDNA测序.
- 建立了关于牙周炎,BPH和综合疾病的老鼠模型.
- 在老鼠前列腺中注射P. gingivalis及其脂多糖 (P.g-LPS),并使用P.g-LPS创建前列腺细胞感染模型.
主要成果:
- 在患有牙周炎的BPH患者的前列腺液中经常检测到P. gingivalis.
- P. gingivalis 感染和 P. g-LPS 显著诱导前列腺上皮质和肌层增生和原纤维化.
- P. gingivalis促进前列腺细胞增殖,抑制了细胞灭亡,并通过Akt通路调高了IL-6,IL-6Rα和gp130,从而驱动了BPH.
结论:
- Porphyromonas gingivalis 在同时患有 BPH 和牙周炎的患者的前列腺液中大量存在.
- P. gingivalis感染有助于BPH的发展.
- BPH的进展可能受到P. gingivalis诱导的炎症和Akt信号通路的激活的影响.
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