晚期尿性神经病变中神经横截面区域:神经超声波试点研究
Jan-Hendrik Tosberg1, Hannah Mork1, Rafael Klimas2
1Department of Neurology and Neurogeriatrics, Johannes Wesling Klinikum Minden, Ruhr-University Bochum, Bochum, Germany.
概括
在末期病 (ESKD) 的尿路性神经病变 (UN) 患者中,长期接受血液透析 (HD),神经截面面积 (CSA) 没有扩大. 减少的外围神经CSA表明轴突损失,而不是神经扩大,在慢性UN.
科学领域:
- 神经学 神经学
- 腎臟病學 (nephrology) 是一種醫學.
- 放射学 放射学是一门学科.
背景情况:
- 尿路性神经病变 (UN) 是一种常见的,残疾性并发症,在末期脏病 (ESKD) 患者接受长期血液透析 (HD).
- 之前的神经超声波研究报告了有关神经截面区域 (CSA) 的相互矛盾的发现.
研究的目的:
- 用超声波检查高级UN患者中多个外围神经的双边CSA.
- 为了将神经CSA和神经传导研究 (NCS) 的发现与临床神经病变的严重程度相关联.
主要方法:
- 双边超声波CSA测量了10名ESKD患者与10名健康对照中的13个手臂和腿部神经.
- 记载了神经传导研究 (NCS) 和总神经病变得分 (TNS).
- 统计分析包括皮尔森的相关性和曼-惠特尼U测试.
主要成果:
- 患有ESKD的患者表现出晚期的神经病症症状 (平均TNS 15.9).
- 在联合国小组中,NCS揭示了运动和感觉幅度显著降低.
- 在13个神经部位中的5个神经部位中观察到神经CSA的轻微减少;没有检测到神经扩大. 外围神经CSA与TNS有负相关性.
结论:
- 长期患有HD的ESKD患者的晚期尿路性神经病变没有神经扩张的特征.
- 减少的外围神经CSA表明轴突损失是慢性HD的结果.
- 在患有急性外周神经系统疾病的ESKD患者中,神经扩大可能表明慢性以外的原因.
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