人格特征和多药学:对五个样本的元分析
Yannick Stephan1, Angelina R Sutin2, Antonio Terracciano3
1Euromov, University of Montpellier, Montpellier, France.
Psychology & health
|May 20, 2024
概括
高度的神经性增加了多药风险,而良心和外向可能会提供保护. 这项研究将人格特征与药物使用模式联系起来.
科学领域:
- 心理学 心理学 心理学
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
背景情况:
- 多药性,即使用多种药物,是越来越令人担忧的,特别是在老龄化人口中.
- 了解影响多药学的因素对于开发有针对性的干预措施至关重要.
- 人格特征越来越多地被认为是健康行为和结果的潜在决定因素.
研究的目的:
- 调查核心人格特征与发展多药的风险之间的潜在关联.
- 检查个性特征是否预测了随着时间的推移使用多种药物的可能性.
- 识别可能增加或减少多药风险的特定人格维度.
主要方法:
- 利用了来自五项大规模纵向研究 (ELSA,MIDUS,HRS,WLS,LISS) 的15,000多名参与者的数据.
- 在基线评估人格特征和人口统计因素,并在2至20年后跟踪药物使用.
- 采用随机效应的元分析来综合各种研究样本中的发现.
主要成果:
- 较高的神经病症水平与多药性 (OR = 1.30) 和过度多药性 (OR = 1.44) 的风险增加有显著关联.
- 相反,更高的良心 (OR = 0.84) 和外向 (OR = 0.85) 与减少多药症的风险有关.
- 没有发现开放性或可接受性和多药性之间存在显著的关联. 身体质量指数,慢性疾病和抑郁症状部分介导了这些关系.
结论:
- 神经病变成为多药学的一个重要风险因素,突出了其在同时使用多种药物中的作用.
- 良心和外向似乎对多药有保护作用.
- 这些发现强调了在药物管理和健康结果的背景下考虑个性的重要性.
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