在患有口腔状体疾病的患者中,自身免疫和上皮质质变形症
Jeong-Hyun Kang1, Ji Eun Kwon2
1Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Republic of Korea.
Oral diseases
|May 20, 2024
概括
自身免疫可能会导致口腔状体疾病中的表皮质质变形. 患有发育不良症的患者表现出较高的抗核抗体 (ANA) 阳性和C反应性蛋白水平,表明与炎症的联系.
科学领域:
- 口腔病理学 口腔病理学
- 免疫皮肤学 免疫皮肤学
- 自身免疫性疾病是一种自身免疫性疾病.
背景情况:
- 口腔状体疾病 (OLD) 包括口腔状体平面 (OLP),口腔状体病变 (OLL) 和口腔状体药物反应 (OLDR) 等疾病.
- 在老年患者中,自身免疫和上皮质质变形之间的关系仍然不完全理解.
- 表皮质发育不良意味着口腔表皮的癌前变化.
研究的目的:
- 调查自身免疫标志物与诊断为口腔状体疾病的患者上皮质发育不良的存在之间的关联.
- 探索系统性炎症在口腔上皮层内失塑性变化的发展中的潜在作用.
主要方法:
- 分析了66名OLP,35名OLL和85名OLDR患者的队列.
- 诊断遵循了经过修改的世卫组织标准;表皮质质变形被单独评估.
- 测量了抗核抗体 (ANA) 的间接免疫光和血清高灵敏性C反应蛋白 (hs-CRP) 水平.
- 进行了直接免疫光 (DIF) 试验.
主要成果:
- 在OLP和OLDR组中,表皮质质变形症患者的抗核抗体 (ANA) 阳性比没有变形症的患者高得多.
- 在OLP,OLL和OLDR患者中观察到血清hs-CRP水平升高.
- 直接免疫光检测显示,在患上上皮质失生症的OLP患者的底层膜区域中,C3沉积的患病率较高.
结论:
- 自身免疫可能会促进慢性炎症,可能导致异常的伤口愈合和老年疾病患者口腔上皮质的失生变化.
- 这些发现表明,潜在的途径将自身免疫过程与口腔癌前病变的发展联系起来.
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