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Updated: Jun 26, 2025

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在大鼠模型中,ALKBH5通过抑制NR2B表达来调节骨癌疼痛

Kun Song1,2, Qionghua Cao3, Yanping Yang1,2

  • 1Department of Anesthesiology, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan, China.

Biotechnology and applied biochemistry
|May 20, 2024
PubMed
概括

N6-甲基氨酸 (m6A) 修饰和ALKBH5通过影响背部根中N-甲基-d-酸盐受体亚单元2B (NR2B) 稳定性来调节骨癌疼痛 (BCP). ALKBH5成为BCP的潜在治疗点.

关键词:
骨癌 疼痛 骨癌 疼痛背部根部的角质组织.m6A 修改 的 修改.

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NF-κB-dependent Signaling Pathway02:26

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The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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