MASLD可以通过小肠细菌过度生长引起口臭
1Department of Gastroenterology and Halitosis Clinic, Minhang Hospital, Fudan University, Shanghai, China.
Oral diseases
|May 20, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 可以通过小肠细菌过度生长 (SIBO) 引起口臭. 这项研究发现,SIBO在MASLD患者中显著增加了口臭严重程度和呼出的二甲基硫化物.
科学领域:
- 胃肠病学 胃肠病学
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 越来越普遍.
- 患有MASLD的患者经常经历口臭,这表明其非口腔原因.
- 小肠细菌过度生长 (SIBO) 是MASLD和口臭的潜在原因之一.
研究的目的:
- 调查SIBO导致MASLD和随后的口外口臭的假设.
- 评估MASLD和口臭患者中SIBO的患病率.
- 量化SIBO对口臭严重程度和特定生物标志物的影响.
主要方法:
- 对885名口外口臭患者进行了回顾性横截面研究.
- 使用纤维扫描和心脏代谢标准诊断MASLD.
- 通过气呼吸试验诊断SIBO.
- 使用感官评分 (OLS) 和通过OralChroma.使用呼出的二甲基硫化物 (DMS) 测量口臭.
主要成果:
- 15.05%的口臭患者患有MASLD;65.41%的这些MASLD患者是SIBO阳性.
- 与SIBO阴性患者相比,SIBO阳性患者的OLS (4vs2) 和呼出的DMS水平 (56vs43ppb) 显著更高 (p<0.001).
- 呼出的水平与OLS和DMS水平有很强的相关性 (r=0.774,r=0.740;p < 0.001).
结论:
- 小肠细菌过度生长 (SIBO) 是患有MASLD.患者口臭症发展的重要因素.
- 在MASLD患者中,SIBO会加剧口臭的严重程度,并提高呼出的二甲基硫化物水平.
- 针对SIBO可能是管理MASLD中口臭的治疗策略.
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