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Updated: Jun 26, 2025

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分子动力学模拟揭示了MGL-3196对甲状腺素受体β抗性的机制

Yi Lu1,2, Chun Chen1, Deyi Zhuang1

  • 1Fujian Key Laboratory of Neonatal Diseases, Xiamen Key Laboratory of Neonatal Diseases, Xiamen Childreǹs Hospital (Children's Hospital of Fudan University at Xiamen), Xiamen 361006, China.

ACS omega
|May 20, 2024
PubMed
概括

MGL-3196,一种用于非酒精性脂肪肝炎 (NASH) 的新药,在具有特定甲状腺素受体β (TRβ) 突变的患者中可能无效. 这些突变,R243Q和H435R,使TRβ对MGL-3196不敏感,影响治疗疗效.

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