在类风湿性关节炎中,心脂肪组织和左心室缩功能通过二维斑跟踪心声学评估
Tinglin Wang1, Gehong Peng1, Hongyu Liang1
1Department of Echocardiography, The Affiliated Hospital of Zunyi Medical University, Zunyi, CHN.
Cureus
|May 20, 2024
概括
类风湿性关节炎患者表现出心表脂肪组织 (EAT) 和亚临床左心室 (LV) 缩功能障碍的增加. EAT积累与减少LV全球纵向应变 (GLS) 有关,但年龄和疾病活性是更强的因素.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 生物标志物 生物标志物
背景情况:
- 脊心脂肪组织 (EAT) 是一个新兴的心血管生物标志物.
- 亚临床左心室 (LV) 系统功能障碍在类风湿性关节炎 (RA) 中普遍存在.
研究的目的:
- 在RA患者中使用2D斑点跟踪心声学 (2D-STE) 评估LV缩功能.
- 在没有临床心血管疾病 (CVD) 的RA患者中研究EAT和LV缩功能之间的关联.
主要方法:
- 招募了60名RA患者和60名健康对照.
- 常规心声学和2D-STE被用于评估LV缩功能和EAT.
- EAT被量化为右心室自由壁和心周之间的无回声区域.
主要成果:
- 与对照组相比,RA患者的EAT增加和全球纵向应变 (GLS) 减少.
- 在RA患者中发现了EAT和GLS之间显著的反相关性 (r=-0.273,P=0.035).
- 在多变量分析后,年龄和疾病活动评分28被确定为影响RAGLS的独立因素.
结论:
- RA 患者有显著增加的 EAT 和 LV 系统功能障碍 (减少 GLS) 的早期迹象.
- 虽然EAT积累与GLS受损相关,但老年和较高的疾病活性是RA中LV功能障碍的更重要的决定因素.
相关概念视频
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
1.2K
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
1.2K
Rheumatic Heart Disease I: Introduction
1.0K
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
1.0K
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
1.3K
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
1.3K


