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双酸盐在停止使用德诺苏马布后对骨矿物质密度的三年影响:来自现实研究的观察结果
Vanina Farias1,2, Fernando Jerkovich1, Andrea Morejón Barragán2
1Instituto de Diagnóstico e Investigaciones Metabólicas (IDIM), ZP 1012, Buenos Aires, Argentina.
JBMR plus
|May 20, 2024
概括
双酸盐有助于维持骨矿物质密度 (BMD) 在denosumab (Dmab) 停用后长达36个月. 这项研究评估了从Dmab过渡到双酸盐治疗的绝经后妇女的BMD变化和骨折发生率.
科学领域:
- 内分泌学 在内分泌学.
- 骨质疏松症研究 骨质疏松症研究
- 药理学 药理学是指药理学的学科.
背景情况:
- 在停止使用德诺苏马布 (Dmab) 后,对长期骨矿物质密度 (BMD) 管理的数据有限.
- 绝经后骨质疏松症的治疗通常涉及连续治疗.
研究的目的:
- 为了评估长期的BMD变化 (12-36个月) 后denosumab (Dmab) 撤销和随后的双酸盐治疗.
- 评估骨周转标志物,影响骨损失的因素和脆弱性骨折的发生率.
主要方法:
- 对54名绝经后妇女进行了回顾性分析,这些妇女先前接受了denosumab (Dmab) 治疗.
- 通过DXA扫描和骨周转标记在Dmab后12个月和36个月评估骨矿物质密度 (BMD).
- 口服与静脉注射双酸盐的比较.
主要成果:
- 在Dmab后的12个月和36个月观察到BMD的下降,在头12个月内,骨循环标志物显著增加.
- 较长的德诺苏马布 (Dmab) 治疗持续时间与12个月后更大的骨质量损失相关,特别是在大腿部.
- 七名患者经历了偶然的脊椎骨折,没有人遵守治疗指南.
结论:
- 双酸盐似乎可以减轻骨矿物质密度 (BMD) 的损失,在停止使用denosumab (Dmab) 后长达36个月.
- 遵守治疗指导方针可能对防止在停止使用登苏马布 (Dmab) 后发生骨折至关重要.
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