主观认知衰退是多么"主观"?
Alexandru Pavel1, Valentin Matei2, Radu Paun2
1Department of Psychiatry, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Psychiatry and clinical psychopharmacology
|May 20, 2024
概括
患有主观认知衰退的个人在口头学习和执行功能方面经历了微妙的客观认知障碍. 这些缺陷可能会被标准认知测试忽略,这表明需要精细的诊断标准.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 老年学是一门学科.
背景情况:
- 主观认知衰退 (SCD) 被认为是神经退行最早的临床阶段.
- 目前的定义并不意味着可测量的认知障碍,但有客观缺陷被报告.
- 这项研究旨在确定SCD患者与健康对照者的客观认知性能差异.
研究的目的:
- 评估主观认知衰退的个体和认知无损的健康对照之间的客观认知表现差异.
- 调查SCD中可能无法通过简短查工具检测到的微妙认知障碍.
- 为了提高SCD诊断标准的准确性,为潜在的修订提供信息.
主要方法:
- 101名认知正常的参与者被分为SCD (n=67) 和健康的对照 (n=34) 组.
- 进行了全面的认知评估,并收集了社会,人口,临床,人格,睡眠和体育活动数据.
- 根据性别,年龄,教育程度以及迷你精神状态考试 (MMSE) 成绩,这些组被匹配.
主要成果:
- SCD组表现出明显较低的口头学习能力,证据是雷听力口头学习测试 (RAVLT) 试验1 (P=.021) 和总分 (P=.023) 的表现较差.
- 与对照组相比,SCD组的执行功能明显受损,根据Trail Making Test A的表现 (P=.012).
- 这些客观障碍是微妙的,不足以诊断轻度认知障碍.
结论:
- 有主观认知衰退的个人表现出微妙的,客观的认知障碍.
- 这些缺陷,特别是在口头学习和执行功能方面,可能会被MMSE等简短的认知评估所遗漏.
- 扩大目前的SCD标准可以提高诊断准确性和临床实用性.
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