接受传染病的好处 药剂师建议:在多医院系统中进行的5年结果研究
Taylor Babiarz1, Justin Schmetterer2, Kelley Merrick2
1Memorial Hermann Northeast Hospital, Humble, TX, USA.
Hospital pharmacy
|May 20, 2024
概括
由传染病药剂师领导的抗菌管理计划 (ASP) 显著减少了抗生素使用和医院费用. 接受的ASP干预措施缩短了住院时间,减少了抗生素治疗日数,但没有对患者的死亡率或再入院产生负面影响.
科学领域:
- 医疗保健服务研究 医疗服务研究
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 传染病 (ID) 药剂师对于抗菌药物管理计划 (ASP) 是至关重要的.
- 预期审计和反是推的ASP策略.
- 在Epic中使用了定制的文档工具 (events) 来评估ASP干预的影响.
研究的目的:
- 评估接受与拒绝的ASP干预措施对临床结果的影响.
- 评估ID药剂师主导的干预措施在多医院系统的有效性超过五年.
主要方法:
- 一项多中心的回顾性队列研究比较了接受和拒绝ASP干预的结果 (2015年10月至2020年12月).
- 结果包括抗生素利用率 (DOT/1000 PD,剂量/1000 PD),停留时间 (LOS),死亡率和Clostridioides difficile感染 (CDI).
- 对混变量进行控制的粗精确匹配 (CEM).
主要成果:
- 观察到ASP干预的整体接受率为92%.
- 接受的干预措施导致抗生素使用量大幅减少,但不增加死亡率或再录取率.
- 接受干预的非ICU患者的LOS缩短了一天,从而避免了大量的成本 (7,631,400美元).
结论:
- 与ID药剂师的合作优化了抗菌药物管理,减少了抗生素的使用,成本和LOS.
- 在不影响患者安全的情况下,ASP干预措施有效地提高了资源利用率.
- 该研究强调了前性审计和反在抗菌药物管理中的价值.
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