肺腺性癌患者的转移模式和预后:基于监测,流行病学和最终结果的人口研究
1Department of Respiration, First People's Hospital of Changzhou, Third Affiliated Hospital of Soochow University, Juqian Road No.185, Changzhou, China.
Heliyon
|May 20, 2024
概括
肺腺性癌 (ASC) 是具有侵略性的,骨,肺,肝脏和大脑是常见的转移部位. 早期检测和治疗对于改善晚期ASC患者的结果至关重要.
科学领域:
- 在瘤学瘤学.
- 肺部医学 肺部医学
- 癌症研究 癌症研究
背景情况:
- 肺腺性癌 (ASC) 是一种罕见但高度侵入性的肺癌亚型.
- 有限的研究存在于先进阶段ASC的转移模式.
研究的目的:
- 在晚期肺腺性癌中表征转移性模式.
- 为了确定与不同转移部位和模式相关的生存结果.
- 评估化疗等治疗对ASC转移患者的生存的影响.
主要方法:
- 对监测,流行病学和最终结果 (SEER) 数据库 (2010-2015) 的分析.
- 描述性统计来定义转移性遗址.
- 卡普兰-梅尔分析对生存率进行比较.
- 考克斯回归用于识别转移的风险因素.
主要成果:
- 骨 (56.9%),肺 (37.6%),肝 (22.1%) 和大脑 (21.4%) 是最常见的转移部位.
- 三个或更多转移部位 (3个月) 的总生存率最差.
- 化疗显著降低了骨,肝脏,大脑和肺部转移的死亡风险.
结论:
- 先进阶段的ASC与预后不佳和显著的转移潜力有关.
- 骨和肺是转移最常见的部位.
- 及时诊断和积极的治疗策略对于改善ASC患者的生存率至关重要.
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