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在评估牛皮关节炎患者的轴参与时,BASDAI与ASDAS对比:两项第三阶段研究的综合分析

Xenofon Baraliakos¹, Dafna D Gladman², Soumya D Chakravarty^3,4

¹Rheumazentrum Ruhrgebiet, Ruhr-University Bochum, Herne, Germany.

Rheumatology advances in practice

|May 20, 2024

概括

根据BASDAI和ASDAS得分,在牛皮关节炎 (PsA) 患者中有效评估轴性疾病活动,无论外周关节是否受到影响,表现都类似. 这些经过验证的工具支持在PSA中监测轴心症状.

科学领域:

类风湿病学类风湿病学
临床评估工具临床评估工具
牛皮关节炎研究研究

背景情况:

当前对牛皮关节炎 (PsA) 中轴性症状的评估通常依赖于不特定于该病症的工具,例如浴脊髓炎疾病活动指数 (BASDAI) 和脊髓炎疾病活动指数 (ASDAS).
需要评估这些广泛使用的指标在PsA患者的表现,特别是那些有轴干涉 (axPsA) 的患者.

研究的目的:

评估BASDAI和ASDAS在评估活跃PSA患者中轴性疾病活动中的性能和实用性.
为了比较BASDAI和ASDAS与各种临床变量之间的相关性,包括外围关节计数,肠炎和患者报告的结果.

主要方法:

来自DISCOVER-1和DISCOVER-2试验的活跃PsA患者的分析,包括带有和没有axPsA的队列.
使用皮尔森系数进行相关性分析,以评估BASDAI/ASDAS与临床变量 (例如,胀关节数,疼痛关节数,疲劳,疼痛,总体评估) 之间的关系.
纵向分析使用混合模型进行重复测量,以评估肠炎,胀关节数和axPsA状态对BASDAI/ASDAS分数的影响.

主要成果:

在基线时,BASDAI和ASDAS与关节计数和肠炎的相关性很弱或不存在,但与疲劳,患者总体评估和axPsA和非axPsA队列中的疼痛有中度到强烈的相关性.
轴参与与显著更高的BASDAI和ASDAS分数相关,两种仪器的性能相似.
周边参数 (胀关节数,肠炎) 和疾病活性得分之间的纵向关联在临床上是无意义的.

结论:

根据BASDAI和ASDAS,在评估活跃PSA患者的轴性疾病活性时,它们表现相似且可靠.
这些评分对于监测PsA的轴性症状是有价值的,无论外周关节参与程度如何.
这些发现支持继续使用BASDAI和ASDAS作为PSA临床试验和实践中的关键结果指标.

关键词:

亚斯达斯 (ASDAS) 是一个巴斯达伊 (BASDAI) 是一个这就是为什么MRI是MRI.临床试验是指临床试验中的临床试验.诊断成像诊断成像的使用.牛皮关节炎牛皮关节炎脊柱脊柱脊柱脊柱脊柱脊髓关节病脊髓关节病脊髓关节病

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