早期多发性硬化症中外围神经变化的演变 - 一项纵向MR神经学研究
Olivia Foesleitner1, Jennifer C Hayes1, Markus Weiler2
1Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Frontiers in neurology
|May 20, 2024
概括
周围神经的参与存在于多发性硬化症 (MS) 诊断时,并且随着时间的推移而演变. 定量MR神经学 (MRN) 检测到MS患者的这些变化,提供了对外围神经的非侵入性监测.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 生物标志物 生物标志物
背景情况:
- 多发性硬化症 (MS) 是一种中枢神经系统脱髓化的疾病.
- 周围神经参与在MS中越来越被认可.
- 了解周围神经的变化对于MS治疗至关重要.
研究的目的:
- 在新诊断的多发性硬化症患者中调查周围神经变化的演变.
- 使用定量MR神经图 (MRN) 来评估外围神经.
- 确定用于检测和监测MS中外围神经参与的生物标志物.
主要方法:
- 对19名新诊断的多发性硬化患者和19名健康对照进行前性研究.
- 使用T2-放松计,使用坐骨神经的高分辨率3T MR神经图.
- 测量了定量生物标志物T2放松时间 (T2app) 和质子自旋密度 (PSD).
- 随访扫描是在平均12个月后进行的.
主要成果:
- 与诊断和随访时的对照组相比,MS患者的T2app增加和PSD减少.
- 在随访时,T2app显著增加,而PSD在MS患者中进一步下降.
- 在一年内观察到周围神经变化的个体变化.
结论:
- 周围神经受影响在MS诊断时是显而易见的,并在第一年内进展.
- 定量MRN提供了用于检测和监测MS中外围神经变化的非侵入性生物标志物.
- 这些发现强调了评估MS中外围神经的重要性.
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