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咖啡摄入量,血咖啡因水平和功能:东亚和欧洲祖先的两个样本孟德尔随机化

Ryosuke Fujii^1,2,3, Masahiro Nakatochi⁴, Fabiola Del Greco M¹

¹Institute for Biomedicine (affiliated to the University of Lübeck), Eurac Research, Bolzano/Bozen, Italy.

Kidney international reports

|May 20, 2024

概括

这项研究发现,在东亚和欧洲人群中,咖啡消费有益于功能,特别是估计的球过率 (eGFRcre). 然而,血咖啡因水平显示出潜在的不良影响,需要对咖啡进行进一步的研究.

科学领域:

遗传学和流行病学
腎臟病學 (nephrology) 是一種醫學專業.
营养科学营养科学

背景情况:

之前关于咖啡和脏健康的门德尔随机化 (MR) 研究在欧洲人口中产生了不一致的结果.
潜在的调解者的作用,如血咖啡因水平,在咖啡-关联中还没有被彻底研究.
需要进行交叉祖先研究,以澄清咖啡摄入量与功能之间的因果关系.

研究的目的:

为了评估咖啡摄入量和功能 (估计的淋巴细胞过率,eGFRcre) 之间的因果关系,在东亚和欧洲祖先中使用两样本的门德尔随机化 (MR).
探索血咖啡因水平在咖啡消费与结局之间的关联中的潜在调解作用.
提供对不同人群的咖啡关联的全面了解.

主要方法:

利用两个样本的门德尔随机化 (MR) 分析,结合来自东亚 (日本) 和欧洲人群的大规模基因组广泛关联研究 (GWAS) 数据.
采用了各种MR方法,包括反变量加权 (IVW),加权中位数,加权模式和MR-Egger,以确保结果的稳定性.
研究了咖啡摄入量和血咖啡因水平与功能之间的关联,特别是根据血清肌素 (eGFRcre) 估计了基于血清肌素过率的估计.

主要成果:

咖啡消费在东亚 (每周咖啡摄入量) 和欧洲 (每天咖啡摄入量) 的祖先中都显示出与eGFRcre的保护性关联,在MR方法中一致.
在东亚和欧洲人群中,较高的血咖啡因水平与较低的eGFRcre相关,这表明潜在的有害影响.
在排除潜在的类基因变异之后,这些发现是强有力的.

结论:

这项交叉祖先MR研究表明,咖啡摄入对估计的淋巴细胞过率 (eGFRcre) 有有益影响.
在较高的血咖啡因水平和较低的EGFRcre之间观察到的关联表明一个复杂的关系,需要仔细解释.
需要进一步的研究,以阐明非咖啡因成分和其他生物途径在咖啡对功能影响中介作用的作用.

关键词:

在CKD中,它是最好的.咖啡因咖啡因是一种咖啡因.咖啡咖啡咖啡咖啡咖啡美国GFRGFR 功能功能功能门德尔的随机化是门德尔的随机化

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