血清参数作为儿童和青少年诊断患有抑郁症的炎症指标
Özlem Önen1, Handan Özek Erkuran1, Özlem Bağ2
1Child and Adolescent Psychiatry Unit, SBU Izmir Dr. Behcet Uz Children's Research and Training Hospital, Izmir, Turkey.
Psychiatry and clinical psychopharmacology
|May 20, 2024
概括
血小板与淋巴细胞的比率在患有严重抑郁症的儿童中较高. 这种血标记物可能有助于临床监测儿科抑郁症.
科学领域:
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 炎症和免疫功能障碍越来越多地与精神疾病有关.
- 系统性炎症标志物如中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR) 和平均血小板体积 (MPV) 在各种疾病中都被利用.
研究的目的:
- 在被诊断患有严重抑郁症 (MDD) 的儿童和青少年中调查NLR,PLR和MPV.
主要方法:
- 一项病例控制研究包括58名患有MDD的儿童和青少年 (9-16岁) 和90名健康对照.
- 数据是在2019年7月至2020年7月期间收集的.
主要成果:
- 与对照组相比,MDD组的血小板与淋巴细胞的比率显著更高.
- 两组之间没有观察到NLR或MPV的显著差异.
- 血小板与淋巴细胞的比率在有或没有自杀史和对照组的抑郁症组之间有显著差异.
- 112.5的PLR切线显示了70%的灵敏度和63%的特异性.
结论:
- 血小板与淋巴细胞的比率可以作为一个有价值的参数,用于临床跟踪主要抑郁症的儿童群体.
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