左心室透的预后价值从T1映射在患有多变性心肌病的患者
Jie Wang1,2, Jinquan Zhang3, Lutong Pu1
1Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
JACC. Asia
|May 20, 2024
概括
从T1绘制的左心室 (LV) 预测高性心肌病 (HCM) 患者的突然心脏死亡 (SCD) 和心血管死亡 (CVD). 增加的LV表明风险更高,作为一个独立的预后标记.
科学领域:
- 心脏病学 心脏病学
- 生物医学成像技术 生物医学成像技术
- 医学诊断 医学诊断 医学诊断
背景情况:
- 左心室 (LV) 在缩性心肌病 (HCM) 的预后影响仍然不完全理解.
- 评估心肌组织特征对于HCM患者的风险分层至关重要.
研究的目的:
- 评估使用T1映射量化的LV的预后值,用于预测HCM患者的不良结果.
- 确定LV能否作为HCM中突然心脏死亡 (SCD) 和心血管死亡 (CVD) 的独立预测因素.
主要方法:
- 心血管磁共振 (CMR) 成像对748名患有HCM的参与者进行了成像.
- 使用本地T1映射测量LV.
- 使用竞争风险和考克斯回归分析来评估LV和SCD/CVD之间的关联.
主要成果:
- 较高的LV (≥4.06) 与SCD和CVD风险增加显著相关 (P <0.05).
- 独立预测的SCD (HR:1.03) 和CVD (HR:1.06) 的LV平均,经过对已确定的风险因素和LGE程度进行调整后.
- 这些发现在整体队列和LGE范围较低的子组中都是正确的.
结论:
- 来自本地T1映射的LV平均,反映了心肌组织异质性.
- LV平均是HCM患者中SCD和CVD的独立预测指标,提供了有价值的预后信息.
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