双极性障碍患者的光学一致性断层扫描发现和相关因素
Aydın Kurt1, Kürşad Ramazan Zor2, Gamze Yıldırım Biçer2
1Department of Psychiatry, Niğde Ömer Halisdemir University, Faculty of Medicine, Niğde, Turkey.
Psychiatry and clinical psychopharmacology
|May 20, 2024
概括
双极性障碍 (BD) 患者显示视网膜神经纤维层 (RNFL) 厚度减少. (Li) 的使用似乎可以保护RNFL神经退行,这表明视网膜成像可以帮助BD诊断和治疗监测.
科学领域:
- 眼科医生 眼科 眼科
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 双极性障碍 (BD) 是一种复杂的精神疾病.
- 神经退行过程与BD病理生理学有关.
- 眼部生物标志物可以提供对BD的见解.
研究的目的:
- 为了研究BD患者的胆叶甲骨层厚度.
- 评估情绪稳定剂 (和酸) 对这些层的影响.
- 为了将视网膜变化与疾病状态和治疗相关联.
主要方法:
- 用光谱域光学连贯性断层扫描 (SD-OCT) 来测量视网膜层.
- 包括67名BD患者 (躁狂,抑郁,缓解) 和49名对照患者.
- 分析了周 papillary 视网膜神经纤维层 (RNFL),黄斑和胸膜厚度.
主要成果:
- 与对照人群相比,BD患者表现出明显较低的周围毛囊RNFL厚度.
- 瓦尔酸使用者与使用者和对照者相比,显示RNFL厚度降低.
- 疾病状态 (躁狂,抑郁,缓解) 并没有显著改变视网膜测量结果.
结论:
- 神经退行性过程可能参与BD.
- (Li) 可能为RNFL提供神经保护性益处.
- SD-OCT衍生的视网膜测量可以作为BD的诊断和预后工具.
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