在SSPE中出现的高动力和低动力运动障碍:对病例报告和病例系列的系统审查
Ravindra Kumar Garg1, Shweta Pandey1, Hardeep Singh Malhotra1
1Department of Neurology, King George's Medical University, Lucknow, India.
概括
亚急性硬化大脑炎 (SSPE) 导致各种运动障碍,最常见的是 dystonia,表明基底腺的参与. 许多患者经历了快速进展和严重的结果.
科学领域:
- 神经学 神经学
- 运动障碍 运动障碍
- 神经炎症是一种神经炎症.
背景情况:
- 亚急性硬化大脑炎 (SSPE) 是一种罕见的,进展性神经系统疾病.
- 虽然SSPE通常与肌结节有关,但可以表现出广泛的运动异常.
- 了解这些不同的运动症状对于诊断和管理至关重要.
研究的目的:
- 审查和描述SSPE超出肌结的运动障碍的范围.
- 为了将这些运动障碍与神经成像发现,疾病进展和患者结果相关联.
- 为了阐明潜在的病理生理学,特别是基底腺干涉.
主要方法:
- 一个系统的审查发表的病例报告和系列的SSPE与非肌痛性运动障碍.
- 遵守PRISMA指南和PROSPERO注册 (CRD42023434650) 的要求.
- 应用迪肯和国际运动障碍学会的诊断和分类标准.
主要成果:
- 从37份报告中分析了39名患者;大多数是男性,平均年龄为13.8岁.
- 最常见的运动障碍是 dystonia (49%),其次是帕金森症和choreoathetosis.
- 快速进展 (≤6个月) 发生在72%的患者中,56%的患者达到同胞性沉默状态或死亡;26%的患者出现基底质病变.
结论:
- SSPE呈现出各种各样的主要是高动力运动障碍.
- dystonia 的高患病率表明在SSPE中存在显著的基底腺功能障碍.
- 这些发现凸显了与SSPE相关的复杂运动表现和不良预后.
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