急性交感激活会使高血压和血管扩张反应对被动腿部运动的反应变得模糊
Brady E Hanson1, Joshua F Lee1, Ryan S Garten2
1University of Utah.
Research square
|May 20, 2024
概括
增加的肌肉交感神经活动 (MSNA) 减少了腿部.
科学领域:
- 心血管生理学心血管生理学
- 自主神经系统的调节规则
- 血管功能 血管功能
背景情况:
- 肌肉交感神经活动 (MSNA) 的增加与衰老和心血管疾病中的血管扩张和血管功能障碍有关.
- 在被动腿部运动 (PLM) 期间,MSNA升高对血管扩张的具体影响仍未得到充分研究.
研究的目的:
- 测试假设增加的MSNA在健康的年轻男性中减弱了被动腿部运动 (PLM) 期间的血管扩张反应.
- 量化MSNA增强对PLM诱导的血管扩张的分级影响.
主要方法:
- 使用运动后的循环阻塞 (PECO) 在对称手握运动后逐渐增加MSNA.
- 评估中央和外周血动力学,并通过神经中微神经图直接测量MSNA.
- 在增强MSNA (ExPECO) 和控制 (ExCON) 条件下,PLM期间血管扩张的比较.
主要成果:
- 在ExPECO试验中,MSNA (爆发发生率) 在25%和40%的最大自愿收缩时显著增加.
- 在PLM期间腿部血管导电量在ExPECO 25%期间减少了16%,在ExPECO 40%期间减少了44%.
- 这些血管扩张的减少根据MSNA升高的水平进行分级.
结论:
- 升高的MSNA显著减弱了对被动腿部运动 (PLM) 的血管扩张反应.
- 在PLM诱导的血管扩张中减弱的程度与交感兴奋的程度直接相关.
- 研究结果强调了交感过度活动在限制血管功能中的作用,即使在年轻,健康的个体中也是如此.
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